darm gezondheid (geen aandoeningen) en vertering digestion intestinal permeability
Conditions
Interventions
In the current study we will have three intervention arms of one week
a bovine
plasma protein intervention, a corn protein intervention and a whey protein
comparator intervention. Study subjects will receive 40 grams of protein per
day during the intervention.
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Age between 35-70y -BMI between 18 - 30kg/m2
Exclusion criteria
Exclusion criteria: - - Intake of medications known to change the inflammatory status (including proton pump inhibitors, anti-inflammatory medication (including NSAIDs) - Having a history of medical or surgical events that may significantly affect the study outcome - Kidney dysfunction (self-reported) - Gastrointestinal disorders, constipation (defecation 5 kg in the month prior to pre-study screening - Reported slimming, medically prescribed, other (extreme) diet, or use of protein concentrates - Not willing to give up blood donation during the study - Current smokers - Alcohol intake > 3 glasses per day - Hard-drug abuse - Participation in other clinical trials in the past month - Being an employee (or student) of the department Consumer Science & Health group of Wageningen Food & Biobased Research Additional exclusion for participation in the postprandial study: - Having blood vessels that are too difficult for inserting a cannula - Anaemia (Hb values
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is to assess the degree of digestibility and protection of the epithelial barrier/ gut permeability. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include other markers of gastrointestinal health, metabolic health, vascular health and satiating properties. | — |
Countries
Netherlands
Outcome results
None listed