Microvasculair function the function of the smaller cardiac blood vessels
Conditions
Interventions
None listed
Sponsors
Maxima Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Asymptomatic athletes with normal exercise electrocardiography results and asymptomatic athletes with concordant abnormal exercise electrocardiography results and abnormal myocardial perfusion scintigraphy results but without the presence of epicardial coronary artery disease.;An athlete is defined as a sportsmen who is engaged in sports for at least 2.5 hours a week for a period of minimally 30 weeks per year or in two or more sports with a minimum of 1.5 hours per week within one type of sports for at least 20 weeks per year
Exclusion criteria
Exclusion criteria: Symptomatic athletes ((Exercise induced) chest pain, palpitations, dizziness, light headiness or syncope), athletes with epicardial coronary artery disease, athletes with previous myocardial infarction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters: * Myocardial blood flow (MBF) per gram of myocardial tissue (ml/min/g) with 82Rb PET-CT imaging. * Myocardial flow reserve (MBF at peak hyperaemia / MBF at rest) with 82Rb PET-CT imaging. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters: * The plasma levels of eNOS and ET-1 in athletes with a normal and abnormal exercise test result. | — |
Countries
Netherlands
Outcome results
None listed