Brain activity in Urticaria Factitia using neurophysiological imaging

Brain activity in Urticaria Factitia using neurophysiological imaging - Brain in Urticaria Factitia

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46276

Enrollment

Registered

2017-06-21

Start date

2017-04-11

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dermographism skin writing

Interventions

Three conditions are studied during the MEG-measurement: baseline situation, local whealing after a histamine prick test, and local whealing after stroking (dermographism).

Magnetoencephalography

Urticaria Factitia

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: UF diagnosed by a dermatologist, in active phase, i.e., wheals arise when antihistaminic drugs are stopped 18 years or older informed consent given

Exclusion criteria

Exclusion criteria: Age

Design outcomes

Primary

Measure	Time frame
- Difference in local and global connectivity between UF patients and healthy controls during the baseline measurement - Difference in local and global connectivity between UF patients and healthy controls after a histamine prick test - Difference in local and global connectivity between UF patients and healthy controls after dermography	—

Secondary

Measure	Time frame
- Differences in the itch score (VAS) before and after a histamine prick test and dermography, DASS and serum levels of CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP between UF patients and the control group. - Correlation between global connectivity after a histamine prick test and the itch score (VAS), area of a histamine prick test wheal and flare, UCT, CU-Q2oL, DASS and serum levels of CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP. - Correlation between global connectivity after dermography and the itch score (VAS), width of the dermography wheal, UCT, CU-Q2oL, DASS and serum levels of CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP In case of detectable regional differences in connectivity measures after a histamine prick test or dermography between UF patients and the control group: - Correlation between local connectivity after a histamine prick test and the itch score (VAS), area of a histamine prick test wheal and flare, UCT, CU-Q2oL, DASS and serum levels of CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP. - Correlation between local connectivity after dermography and the itch score (VAS), width of the dermography wheal, UCT, CU-Q2oL, DASS and serum levels of CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP. *	—

Measure

Time frame

- Differences in the itch score (VAS) before and after a histamine prick test and dermography, DASS and serum levels of CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP between UF patients and the control group. - Correlation between *global connectivity* after a histamine prick test and the itch score (VAS), area of a histamine prick test wheal and flare, UCT, CU-Q2oL, DASS and serum levels of CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP. - Correlation between *global connectivity* after dermography and the itch score (VAS), width of the dermography wheal, UCT, CU-Q2oL, DASS and serum levels of CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP In case of detectable regional differences in connectivity measures after a histamine prick test or dermography between UF patients and the control group: - Correlation between *local connectivity* after a histamine prick test and the itch score (VAS), area of a histamine prick test wheal and flare, UCT, CU-Q2oL, DASS and serum levels of CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP. - Correlation between *local connectivity* after dermography and the itch score (VAS), width of the dermography wheal, UCT, CU-Q2oL, DASS and serum levels of CRH, ACTH, prolactine, cortisol, NGF, BDNF, SP. *

—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)