cognitieve stoornis in het kader van neurodegeneratie early dementia mild cognitive impairment
Conditions
Interventions
None listed
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: between 50-85 years of age MCI (amnestic or multi-domain, CDR=0.5) or mild dementia (CDR=1) native Dutch speaker capable of giving informed consent
Exclusion criteria
Exclusion criteria: MCI due to vascular diseases primary progressive aphasia use of psychotropic medication or recreational drugs serious head trauma or brain surgery neurological or psychiatric disorders (other than MCI) claustrophobia (for MRI-study) large or ferromagnetic metal parts in the head (except for a dental wire; for MRI-study) implanted cardiac pacemaker or neurostimulator (for MRI-study)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EL: The effect of error frequency on memory performance in amnestic MCI and MD by using a novel errorless learning task in which the occurrence of errors is controlled compared to previous work. SP: To assess lexical access and executive function in semantic priming in amnestic MCI and MD by means of a picture-word verification task. | — |
Secondary
| Measure | Time frame |
|---|---|
| EL: To compare the cognitive profile to the outcome on the EL and TEL condition. SP: To assess brain atrophy of frontal and temporal brain areas (using MRI) as well as structural connectivity of pathways connecting these regions (using DWI) in MCI and MD. | — |
Countries
Netherlands
Outcome results
None listed