Diagnostic imaging of synovitis in knee osteoarthritis (DISKO)

Diagnostic imaging of synovitis in knee osteoarthritis (DISKO) - Diagnostic imaging of synovitis in knee osteoarthritis (DISKO)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46234

Enrollment

Registered

2016-06-30

Start date

2017-05-18

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Synovitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age * 18 years; - Clinical signs of knee OA: knee pain (numeric rating scale > 3); - Radiographic signs of knee osteoarthritis (radiographic Kellgren and Lawrence grade *1 ); - Signs of synovitis (i.e. joint effusion) on physical examination of the knee;

Exclusion criteria

Exclusion criteria: - Subjects with a typical (e.g. metallic foreign bodies, etc.) contra-indication for an MRI exam; - Renal insufficiency, checked with blood sample test (GFR

Design outcomes

Primary

Measure	Time frame
Correlations between synovitis visualized on non-contrast DESS and: 1) CE-MRI; 2) Tissue markers of synovial inflammation and specific inflammatory subtypes; 3) Other OA features on MRI; 4) knee OA symptoms and 5) (CE)US findings related to synovitis.	—

Secondary

Measure	Time frame
1. Synovial Ttissue and synovial fluid markers of synovial inflammation and specific inflammatory subtypes; 2. Other OA features on MRI, particularly compositional and morphological change in cartilage and meniscus, altered blood perfusion in synovium and subchondral bone, and osteophyte formation; 3. Knee OA symptoms, especially those related to synovitis (i.e. joint stiffness, self-reported feeling of swelling, pain patterns (constant versus intermittent pain)), recorded with validated standardized questionnaires (like ICOAP, KOOS, VAS and WOMAC). 4. US findings related to synovitis	—

Measure

Time frame

1. Synovial Ttissue and synovial fluid markers of synovial inflammation and specific inflammatory subtypes; 2. Other OA features on MRI, particularly compositional and morphological change in cartilage and meniscus, altered blood perfusion in synovium and subchondral bone, and osteophyte formation; 3. Knee OA symptoms, especially those related to synovitis (i.e. joint stiffness, self-reported feeling of swelling, pain patterns (constant versus intermittent pain)), recorded with validated standardized questionnaires (like ICOAP, KOOS, VAS and WOMAC). 4. US findings related to synovitis

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Countries

Netherlands

Outcome results