Metabolisme HDL-metabolism risk factors for cardiovascular disease
Conditions
Interventions
Subjects will receive both diets for 4 weeks with a wash-out period of 4 weeks
in between. Contrast in the intakes of palmitic acid and stearic acid is 6% of
energy. A postprandial test will be carr
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Apparently healthy men and post-menopausal women (post-menopausal for at least one year) - BMI * 18.0 and * 30.0 kg/m2 - Age: 45-70 yrs - Signed informed consent
Exclusion criteria
Exclusion criteria: - Having a medical condition which might impact study measurements - Use of over-the-counter and prescribed medication, which may interfere with study measurements - Use of oral antibiotics in 40 days or less prior to the start of the study; - Use of food supplements or plant-sterol/stanol-enriched foods or supplements in the three months prior to the screening and/or during the study; - Reported alcohol consumption * 10 units/week (female) or * 14 units/week (male); - Reported intense sporting activities * 10 hours/week; - Reported weight loss or gain of 3 kg or more during a period of 2 months prior to screening - Regular smokers (at least one cigarette (or equivalent) daily or >7 cigarettes (or equivalent) weekly. Smokers who cannot comfortably restrain from smoking for up to 2 days will also be excluded - Reported dietary habits: medically prescribed diet, allergy/intolerance to test products that will be provided during the study - Blood donation in the past 3 months - Drug abuse - Reported participation in another nutritional or biomedical trial 3 months prior to screening - Fasting triacylglycerol concentrations at screening: * 4.5 mmol/L - Serum lipids: treatment recommended according to the *Multidisciplinaire richtlijn Cardiovasculair risicomanagement* - Fasting HbA1c * 48 mmol/mol (or 6.5%)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is the change in HDL metabolism during the fasted state at the end of the dietary period high in palmitic acid versus the dietary period high in stearic acid. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are the effects of palmitic acid versus stearic acid on fasting LDL-C, HDL-C, total cholesterol, the total cholesterol to HDL-C ratio, the LDL-C to HDL-C ratio, non-HDL cholesterol, apoAI and apoB100, and on fasted and postprandial triacylglycerol concentrations. | — |
Countries
Netherlands
Outcome results
None listed