opname van een voedingsmiddel bioavailability uptake
Conditions
Interventions
Study participants will receive a test drink with phospholipid-bound choline,
and a control drink with choline added as a salt.
Sponsors
AAK Netherlands BV
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Apparently healthy men and women * Age between 30 and 70 years * Body mass index (BMI) between 18.5 and 24.9 kg/m2 * Having veins suitable for blood sampling via a catheter (judged by study nurse/ medical doctor)
Exclusion criteria
Exclusion criteria: * Any metabolic, gastrointestinal, inflammatory or chronic disease (such as diabetes, anaemia, hepatitis, cardiovascular disease) * History of gastro-intestinal surgery or having (serious) gastro-intestinal complaints * History of liver dysfunction (cirrhosis, hepatitis) or liver surgery * Kidney dysfunction (self-reported) * Use of medication that may influence the study results, such as laxatives, stomach protectors and drugs that can affect intestinal motility * Use of fishoil or choline supplements * Reported slimming, medically prescribed or vegan diet * Current smokers * Alcohol intake *4 glasses of alcoholic beverages per day * Pregnant, lactating or wishing to become pregnant in the period of the study (self-reported) * Abuse of illicit drugs * Food allergies for products that we use in the study * Participation in another clinical trial at the same time * Being an employee of the department Consumer Science & Health group of Wageningen Food & Biobased Research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is plasma choline, betaine and dimethylglycine measured before and after consumption of a choline drink. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameter is plasma DHA concentrations. | — |
Countries
Netherlands
Outcome results
None listed