heart attack myocardial infarction
Conditions
Interventions
Sponsors
RadboudUMC
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Cases: 20 patients aged between 18 and 50 year, who presented 1-4 years ago with an acute ST-elevation myocardial infarction without classic cardiovascular risk factors.;controls: 20 healthy controls aged 18 or above. controls will be matched with the cases for age, gender and cardiovascular risk factors.
Exclusion criteria
Exclusion criteria: patients: - If the index patient has: o Coagulation disorder o Diagnosis of vascular disease (e.g. previous myocardial infarction, CVA, etc) o If the index patient has two or more of the following factors present:Hypertension o Hypercholesterolemia o Diabetes mellitus Active smoking or an active smoking history within the last 10 years;controles: o Coagulation disorder o Diagnosis of vascular disease (e.g. previous myocardial infarction, CVA, etc) o If the index patient has two or more of the following factors present:Hypertension o Hypercholesterolemia o Diabetes mellitus Active smoking or an active smoking history within the last 10 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral blood samples will be drawn for isolation of monocytes and thrombocytes. The primary endpoint are histone marks of chromatin accessibility such as H3K4 trimethylation (H3K4me3) and H3K9me2 in the promoter region of inflammatory cytokines | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are the cytokine release by monocytes in response to stimulation with Toll-like Receptor(TLR)-agonists and the transformation of monocytes in foam cells. Also the specific blood platelet function in these patients will be examined. | — |
Countries
The Netherlands
Outcome results
None listed