chronic inflammation of the colon inflammatory bowel disease
Conditions
Interventions
The intervention will be an anti-inflammatory diet, rich in vegetables, fruits
and grains, with small amounts of fish and dairy products. Tea and water are
the preferred drinks. Red and processed me
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Diagnosis of Crohn's disease or ulcerative colitis (total or left-sided colitis) made by gastroenterologist and histologically proven - Between 18-75 years of age - Mild disease activity based on CDAI * 150 or SCCAI * 3 - Stable medical therapy for * 2 months - Signed informed consent
Exclusion criteria
Exclusion criteria: - Unwilling or unable to visit the Human Nutrition Research Unit five times per week during the intervention period - Unwilling to strictly follow a diet for four weeks - Participation in another intervention study - Adherence to a vegan lifestyle - Intending to make lifestyle changes during the duration of the study - History of total or partial bowel resection - Use of biologicals (e.g. infliximab, adalimumab, golumimab, ustekinumab, vedolizumab) - More supplement use than the recommended dietary allowance - Not allowing to inform the treating gastroenterologist about the participation - Being an employee or student of Wageningen University, division of Human Nutrition and Health
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is inflammation measured by faecal calprotectin at the beginning and end of each period. Lower values represent less or absence of inflammation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters are clinical disease activity measured by the Crohn's Disease Activity Index (CDAI) in Crohn's disease and the Simple Clinical Colitis Activity Index (SCCAI) in ulcerative colitis, inflammatory markers in blood (CRP, cytokines, whole blood count, ferritin and albumin) and quality of life measured by Inflammatory Bowel Disease Questionnaire (IBDQ). | — |
Countries
Netherlands
Outcome results
None listed