kidney cancer Renal cell carcinoma
Conditions
Interventions
Prior to treatment, patients will undergo fiducial marker placement (in
combination with a biopsy, if RCC has not been pathology proven), followed by a
contrast enhanced planning computed tomography
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Inoperability, or when a patient refuses surgery (i.e. not eligible for (partial-) nephrectomy or RFA); - Kidney function allows for intervention, as evaluated by treating urologist (taking into account eGFR and renogram); - Age * 18 years; - Written informed consent; - Diagnosis of RCC confirmed by pathology (in case determined after informed consent, patients who are not eligible anymore (no RCC) will be excluded).
Exclusion criteria
Exclusion criteria: - Evidence of metastatic disease; - Exclusion criteria for contrast enhanced MRI scan, according to the protocol of the department of Radiology, UMC Utrecht; - Patients with one functioning kidney; - Prior renal surgery (partial nephrectomy); - Prior radiotherapy on upper abdomen; - Unsafe to have fiducial marker implantation: i.e. anticoagulant agents use other than acetylsalicyl acid, which cannot be safely stopped/bridged for implantation; - WHO * 3; - Chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Newly developed acute toxicity grade 3 or more according to the Common Terminology Criteria for Adverse Events (CTC-AE) version 4.0. The treatment is considered successful if all 5 treatments are completed and if in total | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints will be treatment response, (late) toxicity assessment, local control rate and quality of life assessment. | — |
Countries
Netherlands
Outcome results
None listed