Amyloid pathology and vascular disease in focus: exploring interaction in two pathways towards neurodegeneration

Amyloid pathology and vascular disease in focus: exploring interaction in two pathways towards neurodegeneration - Amyloid pathology and vascular disease in neurodegeneration

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46142

Enrollment

700

Registered

2018-07-16

Start date

2018-06-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neurodegeneratieve aandoeningen Dementia vascular pathology

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - persons are eligible who are non-demented; - who had at least one previous complete brain MRI examination and assessment of vascular pathology within The Rotterdam Study; - and who are scheduled for a regular follow-up visit which will include repeat MRI and cognitive testing.

Exclusion criteria

Exclusion criteria: - Contraindications for PET/CT imaging: · hypersensitivity to the active substance (ascorbic acid or ethanol anhydrous) · extreme claustrophobia · inability to lie flat · pregnancy or breastfeeding (not likely in our population).

Design outcomes

Primary

Measure	Time frame
How (progression of) systemic vascular pathology and vascular brain pathology relate to amyloid-* pathology; how amyloid-* and vascular pathologies interact in their association with cognitive function and decline over time.	—

Countries

Netherlands

Outcome results