osteoarthitis
Conditions
Interventions
None listed
Sponsors
LTI
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet the following criteria:;* At least 18 years of age * In regular practice eligible for surgery under spinal anesthesia for o knee joint replacement as treatment for knee OA o A knee VAS pain score (on a scale of 100) either lower than 40 or higher than 60. * Able and willing to give written informed consent
Exclusion criteria
Exclusion criteria: Other (auto) immune disease or diabetes mellitus. Use of (pain) medication other than NSAIDS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokines and chemokines and growthfactors in spinal cerebral fluid measured by LUMINEX. - Patients will be selected based on the clinical parameter knee pain VAS (visual analog scale) specifically for the affected knee. The primary outcome is a normally distributed continuous variable and will be the the level of inflammatory mediators in the spinal cerebral fluid. Knee OA patients will be selected either of having severe pain , defined by as knee VAS>60 or limited clinical pain (knee VAS | — |
Secondary
| Measure | Time frame |
|---|---|
| To asses different aspects of pain we will include additional pain questionnaires. These include: - Intermittent and constant osteoarthritis pain (ICOAP). -The Knee injury and Osteoarthritis Outcome Score (KOOS) score to dichotomize the knee OA patients. - PAINDETECT questionnaire We will also evaluate differences in the following determinants: 2. nerve innervation of the synovium measured by immunohistochemistry of tyrosine hydroxylase (sympathetic nerves) and PGP9.5 (sensory neurons). 3. nerve innervation of the subchondrial junction measured. | — |
Countries
Netherlands
Outcome results
None listed