Global, regional and microvascular hemodynamics during fluid resuscitation following cardiac surgery, a pilot study.

Global, regional and microvascular hemodynamics during fluid resuscitation following cardiac surgery, a pilot study. - The effect of fluid resuscitation on regional perfusion, a pilot study.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON46111

Enrollment

Registered

2016-08-02

Start date

2016-10-18

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamische instabiliteit 1) Hemodynamic optimisation following CABG and/or heart valve replacement/repair. 2) Optimisation of blood flow after heart surgery.

Interventions

Administration of 2 x 250 mL routinely used balanced or unbalanced fluids. See protocol.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age > 18 years ICU admission following elective cardiac surgery Undergoing cardiac output monitoring with a Pulmonary Artery Catheter Need for fluid resuscitation as determined by the treating intensivist

Exclusion criteria

Exclusion criteria: Pregnancy Renal failure (eGFR

Design outcomes

Primary

Measure	Time frame
Renal perfusion: δa.u./δCI - δa.u. (arbitrary units) obtained by CEUS, expressed in percentages - δCI (cardiac index) obtained by swan ganz, expressed in CO/m2 = (mL blood/minute)/m2 Hepatic perfusion: δPDR/δCI - δPDR (plasma disappearance rate) obtained by LiMON, expressed in percentage/minute. - Distribution and clearance of infused fluids by kinetic model analysis, estimating Vc, k10, k12, and k21 using hemoglobin sampling during and after infusion.	—

Measure

Time frame

Renal perfusion: δa.u./δCI - δa.u. (arbitrary units) obtained by CEUS, expressed in percentages - δCI (cardiac index) obtained by swan ganz, expressed in CO/m2 = (mL blood/minute)/m2 Hepatic perfusion: δPDR/δCI - δPDR (plasma disappearance rate) obtained by LiMON, expressed in percentage/minute. - Distribution and clearance of infused fluids by kinetic model analysis, estimating Vc, k10, k12, and k21 using hemoglobin sampling during and after infusion.

—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)