Pilot study investigating the relationship between neurocognitive function, radiotherapy and cerebral white matter microstructure in low grade glioma patients by using MRI diffusion tensor imaging

Pilot study investigating the relationship between neurocognitive function, radiotherapy and cerebral white matter microstructure in low grade glioma patients by using MRI diffusion tensor imaging - MRI DTI following radiotherapy for low grade glioma

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46061

Enrollment

Registered

2018-11-07

Start date

2019-01-03

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain tumor Low grade glioma

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - WHO grade II or III glioma - Radiotherapy received and still in follow-up, both in the UMCG

Exclusion criteria

Exclusion criteria: - Younger than 18 years at the time of glioma diagnosis - Disease progression requiring additional treatment since radiotherapy - MRI contra-indicated

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the correlation between neurocognitive function and DTI abnormalities seen on MRI, expressed in fractional anisotropy (FA). Both will be analyzed as a continuous variable. DTI parameters and cognition will also be related to other MRI parameters.	—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results