Geen aandoening. Een sample uit een gezonde populatie wordt onderzocht op grammaticaverwerving. brain research human cognition
Conditions
Interventions
None listed
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: • Children and adolescents between 8 and 17 years of age • Normal or to normal corrected vision • Normal hearing • Willingness and ability to understand the nature and content of the study
Exclusion criteria
Exclusion criteria: • History of neurological or psychiatric treatment • History of brain surgery or epilepsy • Any current psychological diagnosis according to the DSM criteria. • Any acute or chronic neurological disorders. • Pregnancy • MRI incompatability (metal parts in upper body, implants, medical devices or medicinal plasters) • Claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In the proposed study, the main study parameters are the brain activation patterns and learning success before and after a five-day training in a new natural grammar. The main outcomes of this study are the age-related differences in the neural correlates of grammar learning, i.e. functional MRI BOLD activity. We will relate those neural responses to behavioural learning success (i.e. grammar learning abilities). | — |
Secondary
| Measure | Time frame |
|---|---|
| Additionally, this study aims to investigate individual language-learning differences in relation to the primary dependent variable through several secondary independent variables. Secondary independent variables as predictor for the primary dependent variable: • The proficiency of the English language: this is a composite score of three standardized tests (vocabulary, grammar, and verbal fluency). • Age of acquisition of the English language: a continuous variable in months, assessed through an adapted version of the standardized LEAF questionnaire. Secondary dependent variables that will be investigated in relation to grammar learning abilities (i.e. behavioural scores of Icelandic grammar learning before and after training) are: • Grey matter structures; measured through whole brain structural MPRRAGE brain images. • White matter integrity; fractional anisotropy and mean diffusivity will be calculated from diffusion weighted imaging data and analysed. • Functional connectivity; assessed through a resting-state functional connectivity scan. This approach detects temporal correlations in spontaneous BOLD signal oscillations while subjects rest quietly in the scanner. | — |
Countries
Netherlands
Outcome results
None listed