Detection of retinal and peripheral microvascular abnormalities in ankylosing spondylitis patients * a proof of concept study.

Detection of retinal and peripheral microvascular abnormalities in ankylosing spondylitis patients * a proof of concept study. - An eye for a heart

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46051

Enrollment

Registered

2018-08-23

Start date

2018-10-03

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bechterew's disease microvascular disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Age 50-75 years * Diagnosis of AS according to the 1984 modified New York Criteria

Exclusion criteria

Exclusion criteria: * Diagnosis of diabetes mellitus. * History of an ischaemic stroke or cerebral haemorrhage. * History or evidence of glaucoma, significant cataract or cataract surgery in the 6 months prior. * Active anterior uveitis during the study visit * Rheumatic disease other than related to AS (so: psoriatic arthritis and Inflammatory Bowel Disease are allowed) * Current use of systemic and/or ocular corticosteroids

Design outcomes

Primary

Measure	Time frame
The main study parameters are the aspects of the retinal arterioles and venules, identified with SIVA (Singapore I Vessel Assessment) software of the fundus photos and the retinal thickness and vascular density on (angio) ocular coherence tomography.	—

Secondary

Measure	Time frame
The secondary parameter is the reactive hyperaemia index (RHI), measured with EndoPAT (and calculated automatically by its software). Furthermore, patient characteristics, AS disease characteristics, disease activity parameters, medication, cardiovascular risk factors and diseases, physicical exercise, profession (white or blue collar), laboratory measurements (CRP, ESR, lipid profile) and anthropometric measurements (blood pressure, BMI, arthritis, enthesitis) will be collected.	—

Measure

Time frame

The secondary parameter is the reactive hyperaemia index (RHI), measured with EndoPAT (and calculated automatically by its software). Furthermore, patient characteristics, AS disease characteristics, disease activity parameters, medication, cardiovascular risk factors and diseases, physicical exercise, profession (white or blue collar), laboratory measurements (CRP, ESR, lipid profile) and anthropometric measurements (blood pressure, BMI, arthritis, enthesitis) will be collected.

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Countries

Netherlands

Outcome results