Environmental tobacco exposure (ETS) as a pathway to youth addiction

Environmental tobacco exposure (ETS) as a pathway to youth addiction - Effects of ETS on the development of nicotine addiction

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46046

Enrollment

225

Registered

2016-07-14

Start date

2017-03-06

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rookgerelateerde aandoeningen Addiction

Interventions

None listed

Eligibility

Age

12 Years to 17 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria Experimental Smokers: - Smoked between 5-500 cigarettes - Smoked in the past 6 months - Never smoked daily - Aged between 12 en 18 years old

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded o Head Injury o Regular use of other addictive substances other than nicotine o Use of (psychoactive medication) To take part in the fMRI study the subjects need to be free from metal in or outside the body. Therefore, he or she will be excluded if he or she meets any of the following criteria: Standard exclusion criteria for MRI scanning o* Metal objects or fragments in the body that cannot be taken out o* Active implants in the body o* Using medical plasters o* Epilepsy o* Previous head surgery o* Pregnancy o* Claustrophobia

Design outcomes

Primary

Measure	Time frame
At each wave and during the three weeks of EMA data collection the primary outcome variables will be the PBS: feelings of craving, cue-triggered wanting to smoke, nicotine dependence and behavioral mood and concentration symptoms. These outcomes will be measured by using well-validated questionnaires to measure the occurrence and development of PBS. The primary outcome variable for the EEG study will be the magnitude of the ERP components. ERPs of smoking cue-reactivity (P3 and LPP), non-drug reward sensitivity (P3, FRN and LPP) and impulse control (N2 and P3) will be measured. The primary outcome variable for the fMRI study will be the changes in brain functioning over time in specific brain regions of interest (ROIs) involved in smoking cue-reactivity, non-drug reward sensitivity and impulse control in novice smokers. Brain activity in ROIs of smoking cue-reactivity (NA, amygdala and ACC), non-drug reward sensitivity (NA and vmPFC) and impulse control (IFG, ACC and dlPFC) will be measured immediately after the EMA and once again two years later.	—

Measure

Time frame

At each wave and during the three weeks of EMA data collection the primary outcome variables will be the PBS: feelings of craving, cue-triggered wanting to smoke, nicotine dependence and behavioral mood and concentration symptoms. These outcomes will be measured by using well-validated questionnaires to measure the occurrence and development of PBS. The primary outcome variable for the EEG study will be the magnitude of the ERP components. ERPs of smoking cue-reactivity (P3 and LPP), non-drug reward sensitivity (P3, FRN and LPP) and impulse control (N2 and P3) will be measured. The primary outcome variable for the fMRI study will be the changes in brain functioning over time in specific brain regions of interest (ROIs) involved in smoking cue-reactivity, non-drug reward sensitivity and impulse control in novice smokers. Brain activity in ROIs of smoking cue-reactivity (NA, amygdala and ACC), non-drug reward sensitivity (NA and vmPFC) and impulse control (IFG, ACC and dlPFC) will be measured immediately after the EMA and once again two years later.

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Countries

Netherlands

Outcome results