Mast cell activation in stable versus unstable human atherosclerotic plaques

Mast cell activation in stable versus unstable human atherosclerotic plaques - Mast cell activation in atherosclerosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46044

Enrollment

Registered

2017-08-31

Start date

2017-11-01

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atherosclerosis carotid artery stenosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients undergoing endarterectomy surgery and who are older than 18 years; able to give their consent to enter the study and have signed an informed consent and the agreement form.

Exclusion criteria

Exclusion criteria: Patients younger dan 18 years old. Patients who are not able to give their consent to enter the study Patients who have not signed an informed consent and agreement form

Design outcomes

Primary

Measure	Time frame
The main study parameter is the percentage of mast cell activation in stable versus unstable atherosclerotic plaques.	—

Secondary

Measure	Time frame
1. To investigate whether elevated systemic mast cell markers are correlated to the stability of the atherosclerotic plaque. 2. To investigate correlation of allergies or lung disease with local and systemic mast cell activation in atherosclerosis 3. To investigate the inflammatory status of other immune cells (dendritic cells, macrophages, etc) in atherosclerosis. 4. To investigate whether gender has an effect on immune cell subsets and plaque stability.	—

Measure

Time frame

1. To investigate whether elevated systemic mast cell markers are correlated to the stability of the atherosclerotic plaque. 2. To investigate correlation of allergies or lung disease with local and systemic mast cell activation in atherosclerosis 3. To investigate the inflammatory status of other immune cells (dendritic cells, macrophages, etc) in atherosclerosis. 4. To investigate whether gender has an effect on immune cell subsets and plaque stability.

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Countries

Netherlands

Outcome results