Diabetes mellitus type 1 juvenile Diabetes
Conditions
Interventions
The patients will visit our research unit twice. The first visit consists of a
mixed meal test with a standardised liquid meal followed by an 5g arginine
bolus. On the second visit they will receive
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Diagnosis of diabetes according to the ADA criteria for diagnosis of diabetes mellitus At least 5 years after the first insulin injection History and clinical course consistent with diabetes mellitus type 1
Exclusion criteria
Exclusion criteria: Having had an allergic reaction to arginine and/or GLP-1 (agonists) Use of *-cell stimulants (e.g. sulphonylureas), GLP 1 agonist, dipeptidyl peptidase- IV inhibitors, insulin sensitizers (e.g. metformin, thiazolidinediones) in the 3 months before inclusion Use of medication know to induce insulin resistance (e.g. corticosteroids) in the 3 months before inclusion History of cardiovascular disease (cerebral, coronary or peripheral artery disease), kidney disease (eGFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - the delta maximum concentration of the C-peptide concentration in response to the individual stimuli | — |
Secondary
| Measure | Time frame |
|---|---|
| - delta maximum concentration of the other biomarkers in response to the individual stimuli - Ratios of the C-peptide concentration at the clamp day and the C-peptide concentration at the meal test day after certain stimuli | — |
Countries
Netherlands
Outcome results
None listed