Predicting motor learning with neurophysiological measurements

Predicting motor learning with neurophysiological measurements - Predicting motor learning

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46030

Enrollment

Registered

2017-06-22

Start date

2017-06-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CVA Stroke

Interventions

Motor learning

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Healthy// Aged 18-35// Right handed

Exclusion criteria

Exclusion criteria: History of neurological or psychiatric disorders Implants or metal parts in the head Use of psychoactive drugs in the last month Neuromodulatory stimulation in the last month Pregnant

Design outcomes

Primary

Measure	Time frame
Motor Learning: The accuracy on a sequential visual isometric force pinch task (SVIPT), will be used to measure motor skill. Motor learning is defined as the difference between the first day and the last day. // Local excitation: Local excitation will be measured with a single pulse motor map procedure. A motor map is the area on the skull from which a TMS pulse can stimulate the target muscle. The volume is the sum of the MEP aplitudes in this area// Local inhibition: Local inhibition is mediated by GABAa-ergic and GABAb-ergic interneurons. GABAa-ergic local inhibition will be measured with a paired pulse procedure called short interval intracortical inhibition (SICI). The first pulse is a subthreshold pulse that depolarizes the GABAa-ergic interneurons, which reduces the MEP amplitude of the second suprathreshold pulse. The outcome measure is the amplitude ratio between paired pulses and single pulses. GABAb-ergic local inhibition will be measured with a single pulse procedure called the cortical silent period (cSP). The subject is contracting the target muscle while the magnetic pulse is applied. This produces a short depression of the EMG signal. The outcome measure is the duration of this silent period.// Transcallosal inhibition: Transcallosal inhibition will be measured with a single pulse protocol called the ipsilateral silent period (iSP). The subject is contracting the homologous muscle, ipsilateral of the stimulated motor cortex. The magnetic pulse excites a GABAb mediated transcallosal network that inhibits the contralateral motor cortex, which produces a short depression in the EMG signal of the ipsilateral muscle. The outcome measure is the duration of this silent period.//	—

Measure

Time frame

Motor Learning: The accuracy on a sequential visual isometric force pinch task (SVIPT), will be used to measure motor skill. Motor learning is defined as the difference between the first day and the last day. // Local excitation: Local excitation will be measured with a single pulse motor map procedure. A motor map is the area on the skull from which a TMS pulse can stimulate the target muscle. The volume is the sum of the MEP aplitudes in this area// Local inhibition: Local inhibition is mediated by GABAa-ergic and GABAb-ergic interneurons. GABAa-ergic local inhibition will be measured with a paired pulse procedure called short interval intracortical inhibition (SICI). The first pulse is a subthreshold pulse that depolarizes the GABAa-ergic interneurons, which reduces the MEP amplitude of the second suprathreshold pulse. The outcome measure is the amplitude ratio between paired pulses and single pulses. GABAb-ergic local inhibition will be measured with a single pulse procedure called the cortical silent period (cSP). The subject is contracting the target muscle while the magnetic pulse is applied. This produces a short depression of the EMG signal. The outcome measure is the duration of this silent period.// Transcallosal inhibition: Transcallosal inhibition will be measured with a single pulse protocol called the ipsilateral silent period (iSP). The subject is contracting the homologous muscle, ipsilateral of the stimulated motor cortex. The magnetic pulse excites a GABAb mediated transcallosal network that inhibits the contralateral motor cortex, which produces a short depression in the EMG signal of the ipsilateral muscle. The outcome measure is the duration of this silent period.//

—

Secondary

Measure	Time frame
Assess how the neurophysiological measurements change and interact during multiple sessions of motor training.	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)