hemoglobinopathy thalassemia
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * > 18 years * No regular blood transfusions * Have alpha-thalassemia trait, homozygote alpha thalassemia, Hemoglobin H or other more rare variants where 3 alleles are affected, beta-thalassemia intermedia, iron deficiency anemia or hereditary hemochromatosis * Be able to give informed consent
Exclusion criteria
Exclusion criteria: * Suffering from another serious condition * Fever at time of venepuncture * Inflammatory condition at time of venepuncture * Not able to give informed consent * Regular blood transfusions * Intra venous iron therapy in past 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Investigating ektacytometry in 6 different groups of patients (alpha-thalassemia trait, alpha-thalassemia homozygote, haemoglobin H disease and other more rare variants, beta-thalassemia intermedia, iron deficiency anemia and hereditary hemochromatosis). | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlating ektacytometry data of these patients to clinical data, morphology of RBCs, haematological parameters and iron status, oxidative stress and nitrosylation assays, pyruvate kinase activity and stability, methemoglobin and oxygen saturation. | — |
Countries
Netherlands
Outcome results
None listed