niet van toepassing not applicable
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Employment in one of the participating companies Access to occupational healthcare
Exclusion criteria
Exclusion criteria: None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cr in inhalable and respirable dust sample collected from the air in the breathing zone of the worker by personal air sampling Cr in hand wipe samples collected during the shift Urinary Cr - Cr-U (pre-shift samples, at the end of shift / end of work week) Cr in plasma (collected post-shift and preferably in the end of work week or at least after 1-2 days at work) Cr in red blood cells - Cr-RBC (collected post-shift and preferably in the end of the work-week or after after 1-2 days at work) Hexavalent and trivalent Cr in exhaled breath condensate - Cr(VI)-EBC (before and during the work shift, just before the end of the shift) | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma - PFAS (at the end of the shift / end of the work week) only from chromium platers working with chromium baths in which PFAS containing mist suppressants could have been used Urinary nickel and manganese - Ni-U, Mn-U (at the end of the shift). Urinary nickel levels are suggested to be analysed from welders and those platers performing nickel plating. Urinary manganese levels are analysed from stainless steel welders. Nickel and manganese levels will be analysed in exhaled breath condensate - Ni, Mn - EBC (before and during the work shift, just before the end of the shift). Effects biomarkers in urine: oxidative stress (e.g. malondialdehyde, 8-isoprostane, 8-hydroxy-2-deoxyguanosine) and epigenetic changes (e.g. DNA methylation). Effects biomarkers in whole blood: genotoxicity (micronucleus assay or chromosomal aberrations in peripheral blood reticulocytes or lymphocytes and DNA comet assay plus FPG-modified comet assay), oxidative stress (malondialdehyde, 8-isoprostane, 8-hydroxy-2-deoxyguanosine, Glutathione) and epigenetic changes (e.g. DNA methylation). Cotinine, creatinine | — |
Countries
Netherlands
Outcome results
None listed