Prematuriteit premature birth Prematurity
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: A gestational age of 24 weeks or older at the time of inclusion. An arterial catheter. Written informed consent.
Exclusion criteria
Exclusion criteria: Absence of written informed consent. Skin condition contraindicating transcutaneous measurements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint is the agreement between carbon dioxide values measured with the new sensor and standard of care blood gas sampling. In addition the measurement drift is determined. | — |
Secondary
| Measure | Time frame |
|---|---|
| - To evaluate sensor accuracy during hypercapnia and hypocapnia. - To correlate the transcutaneously measured carbon dioxide levels to the oxygen levels measured with standard of care cerebral near-infrared spectroscopy (NIRS) to determine the vascular influence of CO2 levels on cerebral oxygenation. - To evaluate the influence of the measured ventilation parameters, patient monitoring parameters and hemodynamics including the applied vasopressors on sensor accuracy and functioning - To evaluate the effects of local skin heating by the new sensor as an indicator of application safety using the standard application protocols in our hospital. - To correlate sensor value deviations and drift from blood gas sample values between measured tcPCO2 levels to analyze the effects of skin temperature and vascularization on measurement accuracy. - To evaluate the effect of patient age and time since birth on measurement accuracy. - To assess the measurement quality and accuracy in patients with microcirculatory impairment. | — |
Countries
Netherlands
Outcome results
None listed