Diabetes Insipidus. Frequent urination
Conditions
Interventions
The intervention consists of 12 weeks of treatment, 6 weeks amiloride, 6 weeks
placebo. Additionally, patients are instructed to undergo a water deprivation
test three times, to fill out questionnai
Sponsors
Maasstadziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet the following criteria: -Participant did not experience polyuria before commencing lithium therapy. -All participants are aged 18 years and over. -24 hour urine volume>3L
Exclusion criteria
Exclusion criteria: -Inability to give informed consent -Inability to complete overnight water deprivation test -Patients aged under 18 years -Pregnancy -History of renal disease -Usage of other diuretics that cannot be discontinued -Presence of diabetes insipidus or other etiology -Contraindications for amiloride therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main endpoint is the change in 24 hour urine volume after intervention with amiloride therapy. To examine this, three 24 hour urine samples are collected. The first is collected at the beginning of the study, the second after first six weeks of treatment and the last after the final six weeks of treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of quality of life (SF-36) Frequency of sleep distrubance (ISI) Assessment of the prevalence of diabetes insipidus in patients on lithium therapy Other study parameters include changes in renal function or mean serum lithium concentration. Change in urinary concentrating after study medication Additionally changes in plasma renin and co-peptin will be assessed as measures of extracellular volume status and ADH activity. Change in aquaporin clearance by urinary exosome excretion. | — |
Countries
Netherlands
Outcome results
None listed