bowel movement Gastro-intestinal motility
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy, human volunteers who are willing to undergo minimal bowel preparation and magnetic resonance imaging (MRI) and who are willing to give informed consent.
Exclusion criteria
Exclusion criteria: An age of less than 18 years or more than 45 years, subjects who were unable to give informed consent, the inability to hold breath for 25 seconds, history of abdominal surgery, gastrointestinal diseases or current gastrointestinal symptoms. Furthermore exclusion criteria are (relative) contraindications to undergo MRI; pacemakers, claustrophobia and pregnancy. For the subjects participating in the first part of the study additional exclusion criteria are (relative) contraindications for the use of intravenous injection of butylscopolamine. For the subjects participating in the second part of the study additional exclusion criteria are contraindications for the use of Nutridrink Juice style Apple (the motility modifying substance).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This pilot study is to assess whether these 3D dynamic MRI acquisition and post-processing techniques can be used as a tool to detect and quantify small bowel motility. The main outcome parameter is detection of small bowel motility. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome parameter is the validation and comparison of the two methods by demonstrating the effects of motility modification. | — |
Countries
Netherlands
Outcome results
None listed