Amblyopia lazy-eye
Conditions
Interventions
1) Patching therapy
The non-amblyopic eye will be patched two hours per day. Compliance with
therapy will be monitored with the ODM.
2) Video game
A dichoptic custom-made Unreal Tournament video gam
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Children: Newly diagnosed amblyopia; i.e. never had treatment for amblyopia before with an interocular difference in visual acuity of at least 0.2 logMAR.;Adults: The adult population will be recruited from a previous prospective randomised controlled trial conducted in the Hague in 2001 (MEC-2015-482). In case the amblyopia still persists; i.e. visual acuity difference 0.2 LogMAR lines
Exclusion criteria
Exclusion criteria: Children: Previous amblyopia treatment, a non-comitant or large angle constant strabismus >30Prism dioptres, a neurological disorder, nystagmus, other eye disorders and diminished acuity due to medication, brain damage or trauma.;Adults: a non-comitant or large angle constant strabismus >30Prism Dioptres, a neurological disorder, nystagmus, other eye disorders and diminished acuity due to medication, brain damage or trauma, participants with medical devices or implants that are not certified as MRI-compatible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The visual acuity after 24 weeks of patching therapy (actual dose received) compared to the gaming therapy in adults and children. | — |
Secondary
| Measure | Time frame |
|---|---|
| - The stereoacuity and contrast sensitivity after 24 weeks of patching therapy (actual dose received) compared to the gaming therapy in adults and children. - The fMRI changes in the visual cortex after either treatment in the adult group. - The quality of life in amblyopia treatment with patching therapy compared to gaming therapy. - Investigating information needs for patients to support patient participation in clinical decision making. | — |
Countries
Netherlands
Outcome results
None listed