Veroudering Ageing Sarcopenia
Conditions
Interventions
None listed
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Young * Male, 19-25 years * BMI 18.5-27 kg/m2 * Normal activity levels: 1-2 times per week engaged in a structured exercise session ;Elderly * Male, 65-71 years * BMI 18.5-27 kg/m2 * Normal activity levels: 1-2 times per week engaged in a structured exercise session * Short physical performance battery score >6
Exclusion criteria
Exclusion criteria: * (known symptoms of) Metabolic diseases, e.g. type I or II diabetes, * Health concerns regarding respiratory and pulmonary diseases, e.g. COPD, (exercise induced) asthma and cardiovascular disease. * Impaired physical performance (defined as short physical performance battery score 5 cigarettes per week) * Vastus lateralis skinfold > 30mm (due to tissue penetration depth of near-infrared light) * Haemoglobin concentrations below 8.0 mmol/L * Usage of recreational drugs, e.g. marihuana, amphetamines and cocaine during the study (starting after first screening day) * Recent usage (within four months) of supplements with suggestive training effects, e.g. creatine phosphate, EPO or anabolic steroids. * Current or recent (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is mitochondrial capacity, measured as the rate of recovery of muscle oxygen consumption after exercise measured using NIRS in the vastus lateralis, gastrocnemius and tibialis anterior. | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle acylation status is analysed in muscle biopsies from the vastus lateralis. Physical activity is monitored using a wearable accelerometer over a period of seven days and a 24 hour urine is collected in order to analyse markers of mitochondrial function in urine. Blood is collected to analyse markers of mitochondrial function in plasma. | — |
Countries
Netherlands
Outcome results
None listed