Cerebro vascular accident (CVA) Stroke
Conditions
Interventions
The intervention training will be provided on the C-Mill/3NP. The C-Mill/3NP is
a treadmill that can deliver mechanical and visual perturbations. Visual
perturbations can be projections on the tread
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria have been specified for healthy controls and post-stroke survivors separately. In order to be eligible to participate in the study as a healthy participant, a participant must meet the following criteria: - No history of stroke - Having the capacity to stand and walk *independently* as defined by a Functional Ambulation Categories score 5;In order to be eligible to participate in the study as a post stroke participant , a participant must meet the following criteria: ;- Having sustain a unilateral supratentorial stroke more than 6 months ago, with mild to moderate impairments. - Able to stand and walk independently or under supervision (Functional Ambulation Categories >= 3). - Completed inpatient rehabilitation
Exclusion criteria
Exclusion criteria: People who meet any of the following criteria will be excluded from participation: - Conditions in which physical exercise is contra-indicated. - Unable to walk for 10 minutes without walking aid. - Receiving physiotherapy focusing on balance or gait that cannot be cancelled during participation in this study. - Having received perturbation-based training with visual and/or mechanical perturbations in the past year. - Any other neurological or musculoskeletal conditions affecting balance. - Current orthopaedic problems; hip or knee replacement, or limb amputation. - Severe cognitive problems (Montreal Cognitive Assessment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome of the intervention study is the proportion of individuals with stroke showing normalization of neuromuscular control of balance and gait after the intervention. This is defined as the presence of muscle synergies similar to a reference set of normal muscle synergies. Synergies will be compared pre and post training to determine the effect of DCT. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures that will be assessed are clinimetric parameters such as, Mini-BESTest and Trunk Impairment Scale. Cortical activity will be measured to determine whether there is cortical reorganization after training. For an additional assessment of neuromuscular structures we will determine the change in DMC-index pre and post intervention and will compare these to healthy controls as well. Furthermore, patients will have a follow-up time of 6 months to obtain insights in the occurrence of falls after training. | — |
Countries
Netherlands
Outcome results
None listed