Diagnosis of asthmatic patients using impulse oscillometry; a simple alternative to spirometry.

Diagnosis of asthmatic patients using impulse oscillometry; a simple alternative to spirometry. - Diagnosing asthma with impulse oscillometry/DAWIO

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON45914

Enrollment

Registered

2017-07-17

Start date

2017-10-02

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

asthma asthma bronchiale

Interventions

asthma

diagnosis

impulse

oscillometry

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Adult patients (18 years and older) who are redirected to a secondary health care institute with the presumed diagnosis of asthma who have given informed consent to be included in the study.

Exclusion criteria

Exclusion criteria: Minors below 18 years of age, incapacitated adults and subject who have not signed the informed consent form.

Design outcomes

Primary

Measure	Time frame
The change of the AX area of the impulse oscillometry after taking Ventolin in comparison with the diagnosis of the pulmonary phycicians. The change of the AX area will be used to create an ROC-curve and the best cut off value will be determined. For this cut off value the sensitivity, specificity, positive prediction value, negative prediction value, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio will be determined, including their 95% confidence intervalls.	—

Measure

Time frame

The change of the AX area of the impulse oscillometry after taking Ventolin in comparison with the diagnosis of the pulmonary phycicians. The change of the AX area will be used to create an ROC-curve and the best cut off value will be determined. For this cut off value the sensitivity, specificity, positive prediction value, negative prediction value, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio will be determined, including their 95% confidence intervalls.

—

Secondary

Measure	Time frame
The change of the R5 and X5 of the impulse oscillometry after Ventolin in comparison with the diagnosis of the pulmonary phycicians. The change of the R5 and X5 area will be used to create an ROC-curve and the best cut off value will be determined. For this cut off value the sensitivity, specificity, positive prediction value, negative prediction value, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio will be determined, including their 95% confidence intervalls. The change of the FEV1 of spirometry after Ventolin in comparison with the diagnosis of the pulmonary phycicians. The Mcnemar test will be used to see if there is a significant difference between the diagnostic accuracy of the FEV1 of spirometry in comparison with the AX area of the impulse oscillometry. The correlation between the R5, R20 and AX with the FEV1 will be determined.	—

Measure

Time frame

The change of the R5 and X5 of the impulse oscillometry after Ventolin in comparison with the diagnosis of the pulmonary phycicians. The change of the R5 and X5 area will be used to create an ROC-curve and the best cut off value will be determined. For this cut off value the sensitivity, specificity, positive prediction value, negative prediction value, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio will be determined, including their 95% confidence intervalls. The change of the FEV1 of spirometry after Ventolin in comparison with the diagnosis of the pulmonary phycicians. The Mcnemar test will be used to see if there is a significant difference between the diagnostic accuracy of the FEV1 of spirometry in comparison with the AX area of the impulse oscillometry. The correlation between the R5, R20 and AX with the FEV1 will be determined.

—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)