The cellular and molecular interaction between tumor cells and platelets - role in diagnosis and tumor metastasis.

The cellular and molecular interaction between tumor cells and platelets - role in diagnosis and tumor metastasis. - The role of platelets in gastrointestinal cancer.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON45896

Enrollment

Registered

2018-09-05

Start date

2018-07-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cancer of the intestinal tract gastrointestinal tumors

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Confirmed gastrointestinal tumor: esophageal, stomach or colorectal cancer. Treatment naive.

Exclusion criteria

Exclusion criteria: Not able to give informed consent. Treatment with anticoagulants.

Design outcomes

Primary

Measure	Time frame
1. Tumor education of platelets from patients with GI cancers compared to healthy controls (mRNA profiles, activation status) 2. LMWPTP and PTP1B expressions pattern in oesophageal and gastric cancers and their precursor lesions compared to healthy tissue.	—

Secondary

Measure	Time frame
1. Aggregation and thrombus formation of platelets from GI patients in response to tumor cells in vitro will be compared between GI cancer patients and healthy controls 2. Expression of activation markers on platelets from patients with GI cancer and healthy controls in vitro induced by tumor cells with and without LMWPTP/PTP1B expression (knock down cell lines). 3. Investigation of the molecular pathways activated in tumor cells by activation with platelets from GI cancer patients vs healthy controls, including shedding of NKG2D ligands.	—

Measure

Time frame

1. Aggregation and thrombus formation of platelets from GI patients in response to tumor cells in vitro will be compared between GI cancer patients and healthy controls 2. Expression of activation markers on platelets from patients with GI cancer and healthy controls in vitro induced by tumor cells with and without LMWPTP/PTP1B expression (knock down cell lines). 3. Investigation of the molecular pathways activated in tumor cells by activation with platelets from GI cancer patients vs healthy controls, including shedding of NKG2D ligands.

—

Countries

Netherlands

Outcome results