chronic obstructive pulmonary disease
Conditions
Interventions
The study consists of one exposure session and one control session. Each
session will last approximately 2.25 hours, with the session order selected at
random. Total time at the exposure area is set
Air pollution
Black carbon
Chronic obstructive pulmonary disease
Sponsors
VITO
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: For patients with COPD: - COPD as a primary diagnosis according to the Global Initiative For Chronic Obstructive Pulmonary Lung Disease (GOLD) definition: *Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease with some significant extrapulmonary effects that may contribute to the severity in individual patients. Its pulmonary component is characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lung to noxious particles or gases*. COPD is diagnosed by a chest physician. - Clinically stable on the basis of clinical picture by chest physician . - Treated according to the current international guidelines. - Permission for voluntary participation. Patients will be asked during the first week of their pulmonary rehabilitation at Ciro+ and have to sign an informed consent. Patients have the right to withdraw from the study without any negative consequences on their rehabilitation. ;For healthy control subjects: - No medical history of respiratory or cardiovascular diseases -permission for voluntary participation and signing the informed consent
Exclusion criteria
Exclusion criteria: - Lack of motivation for voluntary participation in this study. - Unable to walk
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory data (spirometry, SpO2, symptoms), cardiovascular data (blood pressure, heart rate, microvascular function), inflammation and vascular blood biomarkers (e.g. total number of WBC, neutrophils and monocytes, CRP, fibrinogen, platelet counts, von Willebrand Factor) collected during and after a 1 hour walk in high and low pollution area, that provide insight in the acute effects of short-term roadside traffic exposure in patients with COPD. | — |
Secondary
| Measure | Time frame |
|---|---|
| - | — |
Countries
The Netherlands
Outcome results
None listed