blood poisoning
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Volunteers: - >18 years old - Healthy male volunteer - Meet eligibility criteria for donating whole blood in the Netherlands - Informed consent;Patients: - ICU patient recovering from sepsis, who have detectable RBC-pathogen complexes in their blood. - * 18 years old - Existing vascular access preferably a double lumen dialysis catheter - Informed consent
Exclusion criteria
Exclusion criteria: Volunteers: - Any abnormal test result during the screening prior to inclusion of the study (medical history, physical examination, and blood examination) - History of drugs or alcohol abuse - Any present medication use on prescription - Participation in any other intervention study during the course of this study;Patients: - Hemodynamic instability as defined by requiring >0.1 mcg/kg/minute of norepinephrine to reach a MAP of > 60 mmHg. - Active bleeding as assessed by the treating physician - Haematological disorders. - Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Reduction of RBC-pathogen complexes after 1 session of apheresis with processing 1.5 times the patients total blood volume which is calculated based on Nadlers formula. - Haematological parameters, such as RBC, platelet and leukocyte counts, before and after apheresis | — |
Secondary
| Measure | Time frame |
|---|---|
| - Vital parameters during apheresis (blood pressure, saturation, pulse, heart rhythm) - total Ca, ionized Ca, lactate, Mg, - SOFA score day of inclusion and day after inclusion - Outcome (28 day mortality) - Duration of ICU stay - Duration of hospital stay - Bloodgas analysis | — |
Countries
Netherlands
Outcome results
None listed