Can a special type of early immune cells trigger loss of saliva production in Sjögren's syndrome?
Conditions
Interventions
None listed
Sponsors
ReumaNederland,
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject in the Sjogren*s syndrome work-up traject must meet all of the following criteria:;• Presents with subjective dry mouth symptoms. • Willing to have exam of oral cavity and a parotid biopsy. • Scheduled for parotid biopsy for routine diagnosis and care. Further classification into non-Sjogren*s syndrome sicca (for example induced through medication), early pSS or pSS, performed based on the decision tree and associated clinical parameters in Figure 1.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: • History of radiation therapy to the head or neck. • Another auto-immune disease, lymphoma, sarcoidosis, hepatitis C, IgG4 disease, HIV (all exclusion criteria for classifying a subject as pSS).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| : For the patient, the harvesting of a parotid gland biopsy represents the endpoint of the activities involved in the ILCSJO study. No further interventions or samples from the patient are required. The biopsy will be harvested during a routine biopsy procedure as part of the diagnostic work-up. | — |
Countries
Netherlands
Outcome results
None listed