Diarrhea
Conditions
Interventions
Following inclusion and informed consent a planned colonoscopy will take place.
This will occur according to standard procedure at each intervention site. At
the time of colonoscopy a colonic lavage
antibacterial
ant-inflammatory
bacteriostatic
clostridium difficile
gastroenterology
honey
irritable bowel syndrome
Manuka
microscopic colitis
Sponsors
TweeSteden ziekenhuis
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: All patients seen at the outpatient clinic in either Elisabeth-TweeSteden Hospital in Tilburg, or the Maastricht University Medical Center with any of the following diagnoses will be eligible for inclusion: ;1. Patients with a persistent clostridium difficile infection who either do not respond to antibiotic therapy or do not tolerate antibiotics;2. Patients with diagnosed microscopic colitis who have received maximum budesonide treatment, and experience relapse of symptoms during step-down dosages, defined as budesonide dependent microscopic colitis ;3. Patients diagnose with irritable bowel syndrome patients of diarrhea subtype according to the Rome IV criteria, whose symptoms persist despite 6 months of treatment via the outpatient clinic ;- Therapy refractory defined as patients with a definitive diagnosis who continue to have a defecation frequency above 3 times daily, with at least one of these times a consistency of 5 or 6 according to the Bristol Stool Scale. ;- A minimum of 1 year follow up;- Age older than 18 years old at diagnosis
Exclusion criteria
Exclusion criteria: - Patients younger than 18 years of age ;- Comorbidities of gastro-intestinal tract;- Drug or alcohol abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome measure: - Frequency of stools - Consistency of stool as measured using the Bristol Stool Scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures - Recurrence of abdominal symptoms after start intervention measured using the Gastro-intestinal Symptom Rating Scale (GSRS) - Recurrance of symptoms attributed to irritable bowel disorder measured using the Birmingham IBS symptom questionnaire - Quality of life (QOL) measured using the Ferrans and Powers QOL-Index | — |
Countries
The Netherlands
Outcome results
None listed