rhTSH and T3 stimulation tests in offspring of long-lived siblings and their partners

rhTSH and T3 stimulation tests in offspring of long-lived siblings and their partners - THYRAGE

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON45854

Enrollment

Registered

2016-05-09

Start date

2016-11-21

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

schildkliermetabolisme en weefselregeneratie in groepen die verschillen in familiaire langlevendheid healthy ageing thyroid metabolism

Interventions

For the rhTSH challenge each participant will receive one intra-muscular (musculus gluteus maximus) injection with a low dose of 0.1 mg (in 1 ml solution) Thyrogen. For the T3 challenge each partic

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Couples will be recruited from the Leiden Longevity Study (LLS), preferably from the 135 subjects that previously participated in the Switchbox phase 1 study, and preferably from the subgroup of 20 couples that were recruited for Group A (P11.116 * Switchbox). All subjects participating in Switchbox phase 1 were healthy, middle-aged (55-77 years) males or females with a BMI in the range of 22.5 kg/m2 to 33 kg/m2. Each couple participating in LLS consists of a child from a family enriched for longevity (case, offspring of long-lived sibling) and his/her current partner (control).

Exclusion criteria

Exclusion criteria: * Cardiac arrhythmias * (History of) thyroid diseases * TSH hoger dan 4.0 mU/l * fT4 level outside the normal range (9-24 pmol/l) * Any significant chronic disease * Renal, hepatic or endocrine disease * Hormone therapy * Difficulties to insert an intravenous cannula * Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year * (History of) alcohol abuse (meer dan 28 units per week) * Nicotine abuse

Design outcomes

Primary

Measure	Time frame
Primary outcome parameters of the study are the (precursor) hormones reflecting the physiological response of the thyroid gland after TSH or T3 stimulation, namely T3, T4, fT3, fT4, Tg and TSH. The levels of these hormones will be compared between offspring of long-lived families and their partners.	—

Secondary

Measure	Time frame
Secondary outcome parameters of the study are processes potentially influenced by thyroid metabolism, namely tissue regeneration, body temperature regulation, heart rate and metabolomics.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)