due to functional constriction or actual obstruction of a blood vessel. MYOCARDIAL ISCHEMIA
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Age > 21 years * Stable angina symptoms, suspected or known CAD, and referred for invasive angiography on clinical grounds. * Ability to provide informed consent * Ability to perform a 20-30 second breath hold
Exclusion criteria
Exclusion criteria: * Hemodynamically and clinically unstable condition (angina at rest, malignant arrhythmias) * Prior, documented myocardial infarction, other than (procedure related) minor type II myocardial infarction, which includes Q waves on the ECG or evidence of myocardial infarction on prior non-invasive imaging. * Coronary artery bypass graft surgery or primary PCI for acute myocardial infarction. * Significant other cardiovascular conditions affecting the interpretation of MPICT, including, but not limited to: clinical heart failure, IECD (pacemaker/ICD), severe valvular heart disease or prosthetic valves, significant intra-cardiac shunting or other relevant congenital heart disease. * eGFR35 kg/m2 * Atrial fibrillation or other arrhythmia, >6 ectopic beats / min * Known or suspected allergy to iodinated contrast medium * Pregnancy cannot be excluded * Contra-indications for adenosine: bronchial asthma, second or third degree atrioventricular block, blood pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myocardial perfusion defect on dynamic CT perfusion imaging, and diagnostic accuracy as compared invasive FFR. | — |
Countries
Netherlands
Outcome results
None listed