This study will evaluate the glycemic response to sucrose with the addition of L-arabinose high blood glucose Hyperglycemia
Conditions
Interventions
We will assess the glycemic and insulinemic responses and glycemic kinetics
after the ingestion of a beverage containing sucrose plus arabinose and compare
those to the ingestion of a beverage conta
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Male/Female - Aged 18-35 y - BMI 18.5 - 25.0 kg/m2 - Healthy - Recreationally active (participating in recreational sports activities
Exclusion criteria
Exclusion criteria: - Smoking - Food allergies - Diagnosed diabetes (type 1 or type 2); fasting glucose >=7.0 mmol/l and/or glucose >=11.1 mmol/l after 2 h OGTT - Diagnosed metabolic or gastrointestinal disorders - Previous participation in a 13C-glucose or 2H-glucose tracer study within the last two weeks - Unstable weight over the last three months - Blood donation in the past two months - Use of medication - High alcohol consumption (>2 drinks per day; >7 drinks per week)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total rate of glucose appearance (RaT), exogenous rate of glucose appearance (RaE), total rate of glucose disappearance (RdT) and exogenous rate of glucose disappearance (RdE) from percentage of [6,6-2H2]-glucose and of ingested 13C-glucose from sucrose-(glucose-13C6) in plasma glucose; plasma glucose and insulin concentrations. | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma FFA and glycerol, whole-body carbohydrate and fat oxidation rates using indirect calorimetry. | — |
Countries
Netherlands
Outcome results
None listed