Associations of circulating elastin degradation products (iso)desmosine with other blood biomarkers, CT-densitometry, arterial stiffness, lung function parameters, and copper in exhaled breath condensate

Associations of circulating elastin degradation products (iso)desmosine with other blood biomarkers, CT-densitometry, arterial stiffness, lung function parameters, and copper in exhaled breath condensate - Correlation densitometry, pulse wave velocity and desmosine level

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON45757

Enrollment

Registered

2019-01-08

Start date

2019-12-05

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Longparenchym: emfyseem COPD (chronic obstructive pulmonary disease) Emphysema

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - COPD Gold I-IV with emphysema on CT thorax - Willful patient - Age 18-75 years - COPD set according to the GOLD criteria; FEV1 / FVC ratio 10 pack / years - Radiologically determined emphysema - Able to undergo a CT scan - Able to undergo lung function examination - Prepared to prick blood - Able to undergo respiratory condensate collection

Exclusion criteria

Exclusion criteria: - Unstable cardiac situation - (active) malignancy - Interstitial lung disease - Status after lung surgery (lobectomy/pneumonectomy) - Pregnancy - Alpha-1 antitrypsin deficiency (MZ is allowed, but PI*ZZ, PI*Z/zero and PI*zero/zero is not allowed)

Design outcomes

Primary

Measure	Time frame
Primary objective: - Correlation of pDES level with CT-longdensitometrie	—

Secondary

Measure	Time frame
Secondary objectives: - Correlation of pDES level with PWV - Correlation of pDES level with lung function tests - Correlation of pDES level with blood biomarkers - Correlation of pDES level with copper concentration in exhalation vapor condensate - Correlation of pDES level with degree of vascular calcification at the site of the carotid siphon artery - Correlation of other biomarkers with each other, CT-lung densitometry, PWV, lung function tests and degree of vascular calcification. the a. carotis siphon	—

Measure

Time frame

Secondary objectives: - Correlation of pDES level with PWV - Correlation of pDES level with lung function tests - Correlation of pDES level with blood biomarkers - Correlation of pDES level with copper concentration in exhalation vapor condensate - Correlation of pDES level with degree of vascular calcification at the site of the carotid siphon artery - Correlation of other biomarkers with each other, CT-lung densitometry, PWV, lung function tests and degree of vascular calcification. the a. carotis siphon

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Countries

Netherlands

Outcome results