eczema hyperkeratoticum et rhagadiforme hyperkeratotic hand eczema
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Written informed consent. - >=18 years old. - Hyperkeratotic hand eczema as defined by the Danish Contact Dermatitis Group - No concomitant diagnose of atopic dermatitis (current)
Exclusion criteria
Exclusion criteria: • Immunosuppressive or immunomodulatory treatment within the last 4 weeks • UV radiation therapy within 4 weeks before biopsy • Active bacterial, fungal or viral infection of the hands • Other skin diseases of the hands • Proven contact sensitization with clinical relevance to the hands, in which exposure to allergens is not avoided • History of psoriasis or psoriasis lesions elsewhere on the body
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the immunofluorescence profile of different keratin proteins, epidermal barrier proteins and adhesion molecules in the skin of patients with hyperkeratotic hand eczema with healthy controls | — |
Secondary
| Measure | Time frame |
|---|---|
| - To compare lesional with non lesional skin of the palms of hyperkeratotic hand eczema patients - To describe the histopathology of hyperkeratotic hand eczema - To describe the ultrastructure and expression of desmosomal components of hyperkeratotic hand eczema compared to healthy controls | — |
Countries
Netherlands
Outcome results
None listed