Biomarkers and (pre-)diastolic dysfunction in the healthy elderly

Biomarkers and (pre-)diastolic dysfunction in the healthy elderly - BIO-PREFER

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON45721

Enrollment

100

Registered

2018-05-02

Start date

2017-01-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diastolic heart failure Heart failure with preserved ejection fraction

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1) Participant need to be 18 or above 18 years old 2) Participant need to be included in Lifelines Deep

Exclusion criteria

Exclusion criteria: 1) Pregnancy

Design outcomes

Primary

Measure	Time frame
To assess whether elevated galectin-3 and BNP could identify apparently healthy elderly subjects that are prone to develop diastolic dysfunction compared to those with low levels, in a case-control study design.	—

Secondary

Measure	Time frame
1. To evaluate if a certain biomarker threshold can be determined to identify subjects at risk to develop diastolic dysfunction 2. To evaluate differences whether or not galectin-3 or BNP are solely elevated to detect diastolic dysfunction 3. To evaluate the influence of genetic variance on the development of diastolic dysfunction 4. To evaluated if vascular stiffness (EndoPat) correlates with cardiac stiffness (diastolic dysfunction)	—

Measure

Time frame

1. To evaluate if a certain biomarker threshold can be determined to identify subjects at risk to develop diastolic dysfunction 2. To evaluate differences whether or not galectin-3 or BNP are solely elevated to detect diastolic dysfunction 3. To evaluate the influence of genetic variance on the development of diastolic dysfunction 4. To evaluated if vascular stiffness (EndoPat) correlates with cardiac stiffness (diastolic dysfunction)

—

Countries

Netherlands

Outcome results