geen van bovenstaande (gezonde proefpersonen) not applicable
Conditions
Interventions
All participants will use a computer game to train spatial cognition for 7
days.
fMRI
Neural development
Nutrition
Spatial cognition
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: Age: 8-10 Healthy fMRI compatible Proficient use of Dutch in both child and parent
Exclusion criteria
Exclusion criteria: - Deafness, blindness, or sensori-motor handicaps - Neuropsychiatric disorders - Diabetes - Chronic inflammatory diseases - Daily use of ibuprofen, aspirin or glucocorticoids - Any recent tooth extraction one month prior to the experiment - History of oral candidiasis - Acute illness with fever, vomiting, or diarrhea within 5 days of the study - Recent use of antibiotics (within 3 months prior to the experiment);Exclusion criteria for MRI: - Non-removable metal in the upper body - Active implant, pacemaker, neurostimulator, insulin pump and/or auditory prosthetic - Epilepsy - Claustrophobia - Brain surgery in the anamnesis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain activation patterns (fMRI) pre and post training are the main outcome measures for this study. These will be related to nutrition and performance. In addition, we will assess the degree to which the aforementioned relationship is mediated by inflammation. | — |
Secondary
| Measure | Time frame |
|---|---|
| The mediating effect of DNA methylation on the relation between nutrition and the brain activation patterns will also be assessed. | — |
Countries
The Netherlands
Outcome results
None listed