Pilot study: A comparison of the extent of haemolysis induced by conventional versus miniaturised extracorporeal circulation during coronary artery bypass grafting surgery, and the influence on the release of damage associated molecular patterns (DAMPs), leukocyte activation and neutrophil extracellular trap (NET) formation.

Pilot study: A comparison of the extent of haemolysis induced by conventional versus miniaturised extracorporeal circulation during coronary artery bypass grafting surgery, and the influence on the release of damage associated molecular patterns (DAMPs), leukocyte activation and neutrophil extracellular trap (NET) formation. - Extent and effect of haemolysis induced by extracorporeal circulation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON45709

Enrollment

Registered

2017-05-29

Start date

2017-09-20

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cell dead of red blood cells haemolysis

Interventions

CABG

Haemolysis

Neutrophils

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Elective CABG operation with extracorporeal circulation

Exclusion criteria

Exclusion criteria: o Kidney insufficiency: creatinine >150 µmol/L o Liver insufficiency: ASAT >80 U/L o Left ventricular function (LVF):

Design outcomes

Primary

Measure	Time frame
The main study parameter is the amount of haemolysis as examined by determining cell free haem/cell free haemoglobin, haemoglobin, haematocrit and lactate dehydrogenase.	—

Secondary

Measure	Time frame
Secondary study parameters are markers for the release of DAMPs (nucleosomes, cell free DNA HMGB1), the activation of leukocytes (calprotectin) and neutrophils (human neutrophil elastase-alpha1 antitrypsin complexes) and the formation of neutrophil extracellular traps (myeloperoxidase(MPO)-nucleosome complexes).	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)