Diabetes type 2 metabolic diseases
Conditions
Interventions
All products contain 50g sucrose and 250g water. The testproducts are:
1) Control sucrose solution (50g sucrose)
2) L-arabinose sucrose solution (Control + 5g L-arabinose)
3) Sucrose and fat solution
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - 18-35 years old while signing the informed consent - good Dutch writing, speaking, understanding - healthy: as judged by the participant - stable body weight, i.e. no reported weight loss or weight gain of >5kg in the two months prior to the screening session - normal Fasting glucose concentration 8.5 mmol/L for men and >7.5 mmol/L for females, measured by finger prick
Exclusion criteria
Exclusion criteria: - women being pregnant or lactating - allergy, intolerance or oversensitivity for food products - having a history of medical or surgical events that may affect the study outcome - having gastro-intestinal problems - medical drug use that may affect the study outcome - current antibiotics usage or in the two months prior to the screening session - not willing to eat or drink the test products - use of dietary supplements that may affect the study outcome - currently using a slimming or medically prescribed diet or having used one in the two months prior to the screening session - excessive alcohol consumption (*21 glasses/week on average) - planning to change physical activity pattern during the study period - having blood vessels that are too difficult for inserting a cannula, as judged by the study nurse - recent blood donation (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcomes are glycaemic and insulinemic response. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are: 1) appetite ratings, 2) subsequent ad libitum energy intake, 3) tolerance of the treatments, 4) gastro-entero endocrine markers, 5) L-arabinose in the blood, and 6) excretion of L-arabinose in urine. | — |
Countries
Netherlands
Outcome results
None listed