verstandelijke beperking intellectual disability mental handicap
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Healthy males and females between 18 and 45 years of age * Sedentary lifestyle (defined as being involved in less than 30 minutes of moderately-intense physical activity per day) * For the ID group: Mild (IQ between 50-70) or moderate (IQ between 35-49) intellectual disability.
Exclusion criteria
Exclusion criteria: * Presence of any known genetic syndrome causing ID (e.g. Down syndrome) * Severe or profound intellectual disability * Motor impairments that would limit treadmill exercise * History of cardiovascular disease, diabetes or any other metabolic disease that may affect the resting and exercise measures * Inflammatory disease * Asthma or other significant respiratory disorders * Cancer in the last six months * Any heart-rate-altering medications or any other medication that may alter metabolic responses * Smoking * Any contraindications to exercise, assessed with the revised Physical Activity Readiness Questionnaire * Pregnancy * Any other contra-indications to performing a maximal exercise test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the oxygen uptake during the maximal exercise test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are heart rate, heart rate variability and blood pressure during exercise and orthostasis. | — |
Countries
Netherlands
Outcome results
None listed