Fuchs endothelial dystrophy / corneal disease
Conditions
Interventions
The intervention includes removal of the diseased DM, endothelial cells and
guttae from the central part of the cornea by manual surgery and/or low energy
YAG laser. This area will be filled in by e
Descemet Membrane
Sponsors
Melles Hoornvlieskliniek Rotterdam (MHR)
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Fuchs endothelial dystrophy - Indication for a corneal transplant - Age * 18 years - Agree to return for 1 day, 1 week, 1 month, 3 months 6 months, 9 months, and 12 months post-procedure follow-up visits
Exclusion criteria
Exclusion criteria: - Concomitant ocular disease and/or a contraindication for this type of treatment (e.g. inflammation of the eye, uveitis etc.) - (Functional) oculus ultimus - Severe diabetes - Unable to sit on a chair in front of the laser for 30 minutes - Unable to clearly understand the language used in the clinic (Dutch) - Inability to give informed consent for any reason - Pregnant or nursing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - visual acuity, measured by the optometrist using a Snellen chart (standard procedure, also used for DMEK). | — |
Secondary
| Measure | Time frame |
|---|---|
| - endothelial cell density, as assessed by specular microscopy and confocal microscopy, - number of complications, - pachymetry of the cornea, measured using a Pentacam apparatus and an Anterior Segment Optical Coherence Tomography apparatus (AS-OCT), - corneal clarity; if the cornea fails to clear within the first 6 months after surgery, the patient will receive a re-operation (DMEK). - intraocular level of inflammation as measured with laser flare photometry | — |
Countries
The Netherlands
Outcome results
None listed