Effects of FASTING duration on cerebral serotonin and dopamine transporter availability in lean and obese subjects

Effects of FASTING duration on cerebral serotonin and dopamine transporter availability in lean and obese subjects - FASTING-study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON45570

Enrollment

Registered

2017-01-11

Start date

2017-03-13

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fasting duration

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Male, age 50-80 years, stable weight three months prior to study inclusion, BMI: 30kg/m2 for obese subjects.

Exclusion criteria

Exclusion criteria: Use of any medication except for those related to treatment of components of the metabolic syndrome. Use of exogenous insulin or oral glucose lowering drugs Any actual medical condition except for treated hypothyroidism and the metabolic syndromeHistory of any psychiatric disorder Shift work Irregular sleep pattern Intensive sports (>3 h/week) Restrained eaters History of eating disorders (anorexia, binge eating, bulimia) Smoking, XTC, amphetamine or cocaine abuse Alcohol abuse (>3 units/day) Lactose intolerance Estimated glomerular filtration rate

Design outcomes

Primary

Measure	Time frame
Differences in cerebral availability of SERT and DAT (assessed by [123I]FP-CIT SPECT) after 12 vs 24 hours of fasting.	—

Secondary

Measure	Time frame
To determine the effect of the fasting duration on peripheral neuropeptides and hormones in relation to cerebral SERT and DAT availability and feeding behaviour To determine the effect of fasting duration on resting energy expenditure (REE) in relation to cerebral SERT and DAT availability and feeding behaviour To determine the effect of fasting duration on appetite and feeding behaviour in relation to cerebral SERT and DAT availability To determine whether fasting affects lean and obese subjects differently	—

Measure

Time frame

To determine the effect of the fasting duration on peripheral neuropeptides and hormones in relation to cerebral SERT and DAT availability and feeding behaviour To determine the effect of fasting duration on resting energy expenditure (REE) in relation to cerebral SERT and DAT availability and feeding behaviour To determine the effect of fasting duration on appetite and feeding behaviour in relation to cerebral SERT and DAT availability To determine whether fasting affects lean and obese subjects differently

—

Countries

Netherlands

Outcome results