The effects of statins on exericse performance the effects of statins on trainingresponse
Conditions
Interventions
12-week combined endurance- and resistance training program
exercise
mitochondria
muscle function
statins and muscle complaints
Sponsors
Integrative fysiologie
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: o Age: 40-70 years old o Current statin user (group 1-2) for at least 3 months o Mentally able/ allowed to give informed consent
Exclusion criteria
Exclusion criteria: o Familial hypercholesterolemia o History of a cardiovascular event within 1 year of study participation o Known hereditary muscle defect o known mitochondrial disease o Diabetes mellitus o Contraindication for maximal incremental exercise test o Contraindication for muscle biopsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aim 1a. Difference in training response between the 3 groups Training response is defined as: * change in aerobic fitness ( maximal incremental cycling test) Aim 1b. * Exercise-induced change in mitochondrial mass and function * Exercise-induced change in substrate use | — |
Secondary
| Measure | Time frame |
|---|---|
| Aim 2. * Exercise-induced change in muscle strength, contractile function and fatigue, mass (voluntary force: 1 repetition maximum; contractility and fatigue assessed by electrical stimulation; mass assessed by DEXA scan) (aim 2) Aim 3. * Exercise-induced change in pain- and fatigue rating, and quality of life | — |
Countries
The Netherlands
Outcome results
None listed