arthritis rheumatoid arthritis
Conditions
Interventions
Not applicable.
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Men and women, * 18 years of age. * Diagnosis of rheumatoid arthritis according to the 1987 revised criteria of the American Rheumatism Association (ARA) and/or the 2010 ACR/EULAR Rheumatoid Arthritis Classification Criteria. * Patients with obvious clinical arthritis activity assessed by a physician, in at least 1 hand, wrist of knee joints. * Treatment with disease modifying anti-rheumatic drugs (DMARDS), biologics and oral corticosteroids up to 10 mg daily is allowed. Non-steroidal anti-inflammatory drugs (NSAID) is permitted, provided that there is a stable dose for at least 1 month. * Patients must be able to adhere to the study appointments and other protocol requirements. * Patients must be capable of giving informed consent and the consent must have been obtained prior to the study related procedures.
Exclusion criteria
Exclusion criteria: * Use of intramuscular or intravenous corticosteroids within 4 weeks prior to screening. * Treatment with any investigational drug within the previous 3 months. * Pregnancy or breast-feeding * Anemia (Hemoglobine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Development of a tracer kinetic model for tracers [11C]DPA-713 and [18F]PEG-Folate. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Development of a static imaging protocol and a validated simplified measure for quantification of uptake of tracers [11C]DPA-713 and [18F]PEG-Folate in arthritic joints in RA patients. 2. Comparison of the static and kinetic model, leading to simplification of protocols for routine clinical studies. | — |
Countries
Netherlands
Outcome results
None listed