Cortical plasticity and Intracortical inhibition in major depressive disorder using transcranial magnetic stimulation

Cortical plasticity and Intracortical inhibition in major depressive disorder using transcranial magnetic stimulation - Plasticity and inhibition in MDD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON45552

Enrollment

Registered

2017-02-28

Start date

2018-02-17

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depression Major depressive disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Unaffected controls: Age: 18-85 years Informed consent Good health Beck Depression Inventory * 9;Inpatients with MDD: Age: 18-85 years Informed consent MDD confirmed diagnosis Initial HAM-D score * 18 Being free of psychotropic drugs for 1 week

Exclusion criteria

Exclusion criteria: Pregnancy Use of psycho-active agents Neurological illness influencing the motor system Not passing the Rossi safety check-list (Rossi et al., 2009)

Design outcomes

Primary

Measure	Time frame
- Intracortical inhibition as measured with the SICI paradigm: the difference in MEP amplitude induced by paired pulse stimulations with a conditioning pulse of 80% RMT and unconditioned single TMS pulses at SI1mV. - Intracortical inhibition as measured with the CSP: the duration of the CSP after a single supratheshold TMS pulse applied at a tonically preactivated FDI muscle, averaged over 20 pulses. - Neuronal plasticity as measured with the iTBS: mean MEP amplitude at the FDI muscle before iTBS (pre-iTBS), and at 5 time points after the iTBS procedure (0 min; 5 min; 10 min; 15 min; 20 min). The iTBS effect is determined as the mean MEP amplitude of the time points after iTBS relative to baseline values.	—

Measure

Time frame

- Intracortical inhibition as measured with the SICI paradigm: the difference in MEP amplitude induced by paired pulse stimulations with a conditioning pulse of 80% RMT and unconditioned single TMS pulses at SI1mV. - Intracortical inhibition as measured with the CSP: the duration of the CSP after a single supratheshold TMS pulse applied at a tonically preactivated FDI muscle, averaged over 20 pulses. - Neuronal plasticity as measured with the iTBS: mean MEP amplitude at the FDI muscle before iTBS (pre-iTBS), and at 5 time points after the iTBS procedure (0 min; 5 min; 10 min; 15 min; 20 min). The iTBS effect is determined as the mean MEP amplitude of the time points after iTBS relative to baseline values.

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Secondary

Measure	Time frame
- Difference in HAM-D score at baseline and after 6 weeks of treatment as usual within the MDD inpatients	—

Countries

Netherlands

Outcome results