pijnstoornissen fibromyalgia
Conditions
Interventions
expectations
extinction learning
fibromyalgia
perception
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Female - 18-65 years old - Able to give written informed consent;Additional inclusion criterion for patient group: - Diagnosed with fibromyalgia by a rheumatologist, according to the ACR criteria (1990 or 2010)
Exclusion criteria
Exclusion criteria: At least one of the following criteria for all subjects: - Significant intellectual or learning disabilities - Visual or hearing disabilities (contacts or glasses are ok) - Obesity (body mass index > 30 kg/m2) - Medical disease such as pulmonary, renal, liver, cardiac, gastro-intestinal, vascular disease - History of chronic alcohol or illicit drug use - Regular use of opioids (tramadol, oxycodone, morphine, fentanyl, etc) - Pregnancy - Use of painkillers or other *rescue* (irregular) medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain-learning task: - Cue effect on reported pain during the extinction phase - Cue effect on heat-evoked skin-conductance responses during the extinction phase - Confirmation bias on learning rate during the extinction phase Visual-discrimination task: - Reported unpleasantness and discrimination accuracy of visual stimulation, as a function of stimulation intensity | — |
Secondary
| Measure | Time frame |
|---|---|
| - Learning rate on the reward-learning task (to assess the specificity of potential learning abnormalities in the patient group to aversive learning situations) - Temporal summation phenomenon - Overall sensitivity to heat pain (self-reported pain and skin-conductance responses to contact heat) - Questionnaire scores (see section 5.2) | — |
Countries
The Netherlands
Outcome results
None listed